All surgical and medical aesthetic procedures are performed personally by Op. Dr. Selman Taşkın
All medical procedures are performed exclusively by Experienced Team.
Nisantasi, Istanbul · Biostimulant / Skin Regeneration

Istanbul Salmon DNA / PDRN Therapy (Plinest, Rejuran)
15+ PDRN Brands Plinest Rejuran Mastelli Korean Original

Medically reviewed by: Op. Dr. Selman TaşkınUpdated:
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“In skin renewal my aim is to support the skin's own quality from within, not just the surface; I target a natural, gradual revitalisation.”

— Op. Dr. Selman Taşkın · Specialist in Plastic, Reconstructive and Aesthetic Surgery
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40+ Salmon PDRN
PDRN
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Salmon DNA / PDRN: Tissue Regeneration Therapy

Salmon DNA / PDRN (Polydeoxyribonucleotide) is polynucleotide complex obtained from salmon fish sperm DNA. When injected under skin, binds to A2A adenosine receptor triggering fibroblast proliferation + collagen production + anti-inflammation + angiogenesis (new capillary formation). Discovered in 1953, used in dermatology since 1990s. Difference from HA filler: not volume — real skin renewal (regeneration). TSHEALTH 15+ premium PDRN brand portfolio.

At TSHEALTH, PDRN is performed by Experienced Team. Mastelli Plinest Classic / Hydro / Smart Skin (Italy) — original, global gold standard, Pharma Research Rejuran S / HB / I / Healer (Korea) — Korean PDRN leader, Promoitalia Nucleofill Soft / Medium / Strong / Eyes, Revitacare Cytocare 532, MD Skin Pluryal Booster, Newest PDRN Korea, Vitrase PDRN, Croma Saypha Rich PDRN. Skin renewal, acne scars, hair loss, post-laser recovery, melasma, chronic wound, joint treatment.

15+ PDRN Brand Portfolio

CE + KFDA + EMA approved, salmon DNA origin premium PDRN brands.

Plinest Classic (Mastelli Italy)Original PDRN — global gold standard, 25+ years of clinical data
Plinest Hydro (Mastelli)Hydration specific — dry skin
Plinest Smart Skin (Mastelli)Specific anti-aging formula
Plinest Eyes (Mastelli)Under-eye tear-trough specific
Plinest Hair (Mastelli)Scalp — PDRN+vitamin complex
Rejuran S (Pharma Research Korea)PN — medium density, acne scar
Rejuran HB (Pharma Research)PN + HA — hydration combination
Rejuran I (Pharma Research)PN — under-eye specific (i = Eye)
Rejuran Healer (Pharma Research)High concentration — post-laser recovery
Newest PDRN (Korea)Korean alternative PDRN — affordable price
Nucleofill Soft (Promoitalia)PN + HA hybrid thin skin
Nucleofill Medium (Promoitalia)Medium density universal
Nucleofill Strong (Promoitalia)High concentration
Nucleofill Eyes (Promoitalia)Tear-trough specific
Cytocare 532 (Revitacare)PDRN + 32-element multivitamin
Pluryal Booster (MD Skin)PDRN + HA eye specific
Saypha Rich PDRN (Croma)Austrian PDRN brand
Vitrase PDRNClassic formula
30G Needle / 32G Micro-needleMicro-injection — mesotherapy technique
31G Liquid Mesotherapy GunU225 Mesogun — homogeneous distribution

PDRN Indications

Skin Anti-Aging

Face/neck/décolleté micro-injection — collagen + elastin renewal.

Atrophic Acne Scars

Direct injection to scar base — fibroblast activation.

Hair Loss (AGA)

Plinest Hair scalp mesotherapy — follicle renewal.

Post-Laser Recovery

Rejuran Healer post-fractional laser — rapid recovery.

Melasma + Pigmentation

PDRN anti-melanin effect — pigment reduction.

Tear-Trough (Under Eye)

Plinest Eyes / Rejuran I / Nucleofill Eyes — skin renewal.

Striae & Cellulite

Body stretch marks — microneedling + PDRN.

Chronic Wound & Joint

Topical on wound/intra-articular — regeneration.

PDRN Process

01
Consultation + Brand SelectionExperienced Team skin analysis + target → brand. Plinest: global gold standard. Rejuran: Korean leader. Nucleofill: hybrid. Cytocare 532: complex formula.
02
Cleansing + Topical AnesthesiaChlorhexidine cleansing. EMLA 20 minutes. Some brands lack lidocaine — anesthesia needed.
03
Micro-Injection (Mesotherapy Technique)Superficial intradermal (papillary dermis) micro-injection with 30G / 32G micro-needle, 1-1.5 cm intervals. Or homogeneous distribution with U225 Mesogun. Total 2-4 ml for face, 4-6 ml neck+décolleté. Duration: 20-30 minutes.
04
Aftercare + SeriesCold application. No water+sun+exercise 24 hours. 3-4 sessions, 2-4 weeks apart. Effect visible in 2-3 months (collagen production slow). Maintenance additional session after 6-9 months.

PDRN at TSHEALTH

Safety

PDRN is among the safest biostimulant treatment groups — completely metabolized by body (DNA-based). Side effects: 1-3 days tenderness at injection site, mild redness, rarely minor bruising. No systemic side effect. Very rare: Salmon allergy (patients know, allergy test before), infection (<0.5%). Contraindications: Active skin infection, salmon/fish allergy, pregnancy (insufficient clinical data), breastfeeding (insufficient clinical data), active cancer (5 years), autoimmune (scleroderma — relative), isotretinoin in last 6 months, hypertrophic keloid history (rarely). Not used for children (no clinical data).

FAQ

What is PDRN?
Polydeoxyribonucleotide — polynucleotide complex obtained from salmon fish sperm DNA. Binds to A2A adenosine receptor triggering fibroblast proliferation + collagen production + anti-inflammation + angiogenesis. Skin renewal + tissue regeneration.
Plinest vs Rejuran difference?
Both PDRN but different origin: Plinest (Italy): Mastelli, original PDRN, global gold standard (25+ years clinical), polynucleotide. Rejuran (Korea): Pharma Research, Asian PDRN leader, polynucleotide (PN). Both effective — Plinest classic, Rejuran Korean innovation.
Difference from HA filler?
HA filler: Volume — mechanical fills, immediate effect, 6-18 months. PDRN: No volume — skin renewal, collagen production 2-3 months, 6-9 month effect. Real 'skin renewal' for PDRN — mechanical fill for HA. Often used together.
How many sessions?
Standard 3-4 sessions, 2-4 weeks apart. Face anti-aging: 3 sessions. Acne scar: 4-6 sessions. Hair loss: 4-8 sessions. Maintenance after 6-9 months.
When results?
2-4 weeks: first hydration + glow. 2-3 months: collagen production result — real change. 4-6 months: maximum effect. Lasts 6-9 months.
Salmon allergy a problem?
Yes — not used in fish/salmon allergic patients as salmon DNA based. Patients know. Allergy test in suspicious cases.
Pregnant/breastfeeding can use?
NO — insufficient clinical data, contraindicated. Can start after pregnancy and breastfeeding ends.
Effective for acne scars?
YES — gold standard treatment for atrophic acne scars. Direct injection to scar base + fibroblast activation. Microneedling combination most effective. 4-6 sessions 40-60% improvement.
Who performs Salmon DNA PDRN Plinest Rejuran?
Salmon DNA PDRN Plinest Rejuran and all aesthetic and surgical procedures are planned and personally performed by Op. Dr. Selman Taşkın, Specialist in Plastic, Reconstructive and Aesthetic Surgery. A graduate of İstanbul University-Cerrahpaşa Faculty of Medicine with reconstructive microsurgery experience at Chang Gung Memorial Hospital (Taiwan), Dr. Taşkın's expertise is the foundation of safe, natural results.
What is a skin booster / biostimulator?
These are treatments injected into the skin that, rather than adding volume, stimulate the skin's own collagen and elastin production to give hydration, glow and firmness.
What is a skin booster used for?
It is used to improve skin quality, reduce fine lines and dullness, and increase hydration and firmness on the face, neck, décolleté and hands.
What is the difference between a skin booster and filler?
Filler adds volume to a specific area, while a booster spreads through the skin to strengthen its own structure; they are often complementary procedures.
How many sessions does a skin booster need?
An initial course of 2–3 sessions at 2–4 week intervals is usually recommended, followed by occasional maintenance to preserve the result.
When are results seen?
An initial freshness is noticed within a few weeks; because collagen renewal takes time, the most visible result appears once the course is completed.
Is the application painful?
It is done with very fine needles and numbing cream is applied if needed, so discomfort is minimal; the procedure is short.
What is recovery like after the procedure?
Mild redness or small bumps at the injection points settle within a few hours; most people return to daily life the same day.
How long does it last?
The effect usually lasts 6–12 months depending on the person and product; with regular maintenance sessions skin quality is preserved for a long time.
How often should it be repeated?
After the initial course, a maintenance session every 6–12 months is usually recommended to preserve the result.
Who can have a skin booster?
Most healthy adults wanting to improve skin quality are suitable; it is not given to pregnant or breastfeeding women or those with an active skin infection, and I assess suitability.

Complimentary Consultation

Complimentary consultation from Experienced Team to select right PDRN brand from 15+ options.

+90 212 561 23 22

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